description
AMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in the cellular AMP:ATP ratio caused by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose or oxygen) or that accelerate ATP consumption (eg, muscle contraction). Several upstream kinases, including liver kinase B1 (LKB1), calcium/calmodulin kinase kinase-beta (CaMKK beta), and TGF-beta-activated kinase-1 (TAK-1), can activate AMPK by phosphorylating a threonine residue on its catalytic alpha-subunit. Once activated, AMPK leads to a concomitant inhibition of energy-consuming biosynthetic pathways, such as protein, fatty acid and glycogen synthesis, and activation of ATP-producing catabolic pathways, such as fatty acid oxidation and glycolysis

external resources
NCBI:989139
KEGG:hsa04152
PUBMED:22885100
PUBMED:18725075
PUBMED:22700795
PUBMED:19724019
PUBMED:19584320
PUBMED:16644802
PUBMED:20010958
PUBMED:16479585
PUBMED:19197243
PUBMED:23565491
PUBMED:20357764
PUBMED:16723978
PUBMED:16054041
PUBMED:19393004
PUBMED:23899560
PUBMED:17307971
PUBMED:15509864
PUBMED:23024365
PUBMED:23747347
PUBMED:19629071

genes
ACACA , ACACB , ADRA1A , AKT1 , AKT2 , CCND1 , CCNA2 , CD36 , CFTR , CPT1A , CPT1B , CREB1 , EEF2 , EIF4EBP1 , ELAVL1 , FASN , FBP1 , FOXO1 , FOXO3 , MTOR , G6PC , GYS1 , GYS2 , HMGCR , HNF4A , IGF1 , IGF1R , INS , INSR , IRS1 , LEP , LEPR , LIPE , RAB8A , PCK1 , PCK2 , PDPK1 , PFKFB1 , PFKFB2 , PFKFB3 , PFKFB4 , PFKL , PFKM , PFKP , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PPARG , PPP2CA , PPP2CB , PPP2R1A , PPP2R1B , PPP2R2A , PPP2R2B , PPP2R2C , PPP2R3A , PPP2R5A , PPP2R5B , PPP2R5C , PPP2R5D , PPP2R5E , PRKAA1 , PRKAA2 , PRKAB1 , PRKAB2 , PRKAG1 , RAB2A , RHEB , RPS6KB1 , RPS6KB2 , SCD , SLC2A4 , SREBF1 , STK11 , MAP3K7 , TSC1 , TSC2 , ULK1 , IRS4 , PIK3R3 , IRS2 , FBP2 , CCNA1 , RAB11B , ADIPOQ , CREB5 , AKT3 , CREB3 , CAMKK2 , RAB10 , PPARGC1A , TBC1D1 , SIRT1 , MLYCD , PPP2R3B , EEF2K , ADIPOR1 , PRKAG2 , RAB14 , CAB39 , PRKAG3 , PPP2R3C , STRADB , PPP2R2D , RPTOR , G6PC2 , CREB3L2 , ADIPOR2 , SCD5 , CAB39L , AKT1S1 , CREB3L3 , CREB3L1 , STRADA , G6PC3 , CPT1C , CREB3L4 , CRTC2 ,