description
Lipolysis in adipocytes, the hydrolysis of triacylglycerol (TAG) to release fatty acids (FAs) and glycerol for use by other organs as energy substrates, is a unique function of white adipose tissue. Lipolysis is under tight hormonal control. During fasting, catecholamines, by binding to Gs-coupled-adrenergic receptors (-AR), activate adenylate cyclase (AC) to increase cAMP and activate protein kinase A (PKA). PKA phosphorylates target protein such as hormone-sensitive lipase (HSL) and perilipin 1 (PLIN). PLIN phosphorylation is a key event in the sequential activation of TAG hydrolysis involving adipose triglyceride lipase (ATGL), HSL, and monoglyceride lipase (MGL). During the fed state, insulin, through activation of phosphodiesterase-3B (PDE-3B), inhibits catecholamine-induced lipolysis via the degradation of cAMP

external resources
NCBI:1222950
KEGG:hsa04923
PUBMED:24676492
PUBMED:21241784
PUBMED:17313320
PUBMED:21900692
PUBMED:20025992
PUBMED:19375517
PUBMED:22298655
PUBMED:19464318
PUBMED:24872083
PUBMED:19136990
PUBMED:19796963
PUBMED:18762440
PUBMED:17878492
PUBMED:24731595
PUBMED:17218471

genes
ADCY1 , ADCY2 , ADCY3 , ADCY5 , ADCY6 , ADCY7 , ADCY8 , ADCY9 , ADORA1 , ADRB1 , ADRB2 , ADRB3 , AKT1 , AKT2 , AQP7 , CGA , FABP4 , GNAI1 , GNAI2 , GNAI3 , GNAS , INS , INSR , IRS1 , LIPE , NPY , NPR1 , NPY1R , PDE3B , PIK3CA , PIK3CB , PIK3CD , PIK3R1 , PIK3R2 , PLIN1 , PRKACA , PRKACB , PRKACG , PRKG1 , PRKG2 , PTGER3 , PTGS1 , PTGS2 , TSHB , TSHR , IRS4 , PIK3R3 , IRS2 , AKT3 , PLA2G16 , MGLL , ABHD5 , PNPLA2 , ADCY4 ,