description
The aspartyl-protease renin is the key regulator of the renin-angiotensin-aldosterone system, which is critically involved in extracellular fluid volume and blood pressure homeostasis of the body. Renin is synthesized, stored in, and released into circulation by the juxtaglomerular (JG) cells of the kidney. Secretion of renin from JG cells at the organ level is controlled by the four main mechanisms: the sympathetic nervous system, the local JG apparatus baroreflex, the macula densa mechanism, and several hormones acting locally within the JG apparatus. Renin secretion at the level of renal JG cells appears to be controlled mainly by classic second messengers, namely cAMP, cGMP, and free cytosolic calcium concentration. While cAMP generally stimulates renin release and the intracellular calcium concentration suppresses the exocytosis of renin, the effects of cGMP in the regulation of the renin system are more complex as it both may stimulate or inhibit renin release

external resources
NCBI:1222951
KEGG:hsa04924
PUBMED:24944035
PUBMED:22733355
PUBMED:20936939
PUBMED:12949225
PUBMED:17360952
PUBMED:17928544
PUBMED:19948673
PUBMED:12388321
PUBMED:15283749
PUBMED:22237158
PUBMED:22258323
PUBMED:9882634
PUBMED:20393195
PUBMED:22124804

genes
ADCY5 , ADCY6 , ADCYAP1 , ADCYAP1R1 , ADORA1 , ADRB1 , ADRB2 , ADRB3 , AGT , AGTR1 , AQP1 , CACNA1C , CACNA1D , CACNA1F , CACNA1S , CALM1 , CALM2 , CALM3 , CALML3 , CLCA1 , CREB1 , CTSB , ACE , EDNRA , GNAI1 , GNAI2 , GNAI3 , GNAQ , GNAS , GUCY1A2 , GUCY1A1 , GUCY1B1 , ITPR1 , ITPR2 , ITPR3 , KCNJ2 , KCNMA1 , NPR1 , PDE1A , PDE1C , PDE3A , PDE3B , PDE1B , PLCB2 , PLCB3 , PLCB4 , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PRKACA , PRKACB , PRKACG , PRKG2 , PTGER2 , PTGER4 , REN , CLCA2 , CLCA4 , PLCB1 , CALML5 , ORAI1 , CALML4 , CALML6 ,