description
The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA

external resources
NCBI:1268683
REACTOME:R-HSA-72662
PUBMED:9732867
PUBMED:592399
PUBMED:641056
PUBMED:6853548

genes
EIF1AX , EIF2S1 , EIF2S3 , EIF4A1 , EIF4A2 , EIF4B , EIF4E , EIF4EBP1 , EIF4G1 , FAU , EIF3E , RPSA , RPS2 , RPS3 , RPS3A , RPS4X , RPS4Y1 , RPS5 , RPS6 , RPS7 , RPS8 , RPS9 , RPS10 , RPS11 , RPS12 , RPS13 , RPS14 , RPS15 , RPS15A , RPS16 , RPS17 , RPS18 , RPS19 , RPS20 , RPS21 , RPS23 , RPS24 , RPS25 , RPS26 , RPS27 , RPS27A , RPS28 , RPS29 , EIF4H , EIF3A , EIF3B , EIF3C , EIF3D , EIF3F , EIF3G , EIF3H , EIF3I , EIF3J , EIF2S2 , EIF3M , PABPC1 , EIF3K , RPS27L , EIF3L , RPS4Y2 , EIF3CL ,