description
TriC/CCT forms a binary complex with unfolded alpha- or beta-tubulin (Frydman et al., 1992; Gao et al., 1993). The tubulin folding intermediates produced by TriC are unstable (Gao et al., 1993). Five additional protein cofactors (cofactor A-E) are required for the generation of properly folded alpha- and beta-tubulin and for the formation of alpha/beta-tubulin heterodimers (Gao et al., 1993) (Tian et al., 1997, Cowan and Lewis 2001)

external resources
NCBI:1268697
REACTOME:R-HSA-389960
PUBMED:1361170
PUBMED:9265649
PUBMED:8096061
PUBMED:11868281

genes
CCT6A , TCP1 , CCT3 , TUBA4A , TUBA3C , TUBB2A , TUBA1A , TUBA1B , TUBB3 , TUBB4A , TUBB4B , CCT7 , CCT4 , CCT2 , CCT6B , CCT8 , CCT5 , TUBA8 , TUBAL3 , TUBA4B , TUBB1 , TUBB6 , TUBA1C , TUBA3E , TUBA3D , TUBB2B ,