description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake

external resources
NCBI:83042
KEGG:hsa03320
PUBMED:15673477
PUBMED:15828221
PUBMED:14999402
PUBMED:15828222
PUBMED:16601267
PUBMED:15828220
PUBMED:10529898
PUBMED:15828223
PUBMED:16476485
PUBMED:11921433
PUBMED:16511590
PUBMED:16360030

genes
ACAA1 , ACADL , ACADM , ACOX1 , PLIN2 , APOA1 , APOA2 , APOC3 , AQP7 , CD36 , CPT1A , CPT1B , CPT2 , CYP7A1 , CYP8B1 , CYP27A1 , DBI , EHHADH , FABP4 , FABP1 , FABP2 , FABP3 , FABP5 , FABP6 , FABP7 , ACSL1 , ACSL3 , ACSL4 , GK , GK2 , HMGCS2 , ILK , LPL , ME1 , MMP1 , OLR1 , PCK1 , PCK2 , PDPK1 , PLIN1 , PLTP , PPARA , PPARD , PPARG , RXRA , RXRB , RXRG , SCD , SCP2 , UBC , UCP1 , ACOX2 , ACOX3 , ADIPOQ , FADS2 , NR1H3 , SORBS1 , SLC27A5 , SLC27A4 , SLC27A2 , ACSBG1 , ACSL6 , SLC27A6 , ANGPTL4 , ACSL5 , SCD5 , ACSBG2 , APOA5 , CPT1C , SLC27A1 , PLIN5 , PLIN4 ,