description
Alpha and beta tubulin folding intermediates are formed through ATP-dependent interaction with TriC/CCT. In order to form a functional heterodimer, these folding intermediates undergo a series of interactions with five proteins: (cofactors A-E) following release from TriC/CCT (reviewed in Cowan and Lewis et al., 2001). These interactions are described in the reactions below. Ultimately, alpha tubulin, when associated with cofactor E, interacts with cofactor D-bound beta-tubulin. The entry of cofactor C into this complex results in the discharge of native heterodimer triggered by GTP hydrolysis in beta tubulin (Tian et al., 1997)

external resources
NCBI:1268700
REACTOME:R-HSA-389977
PUBMED:17709011

genes
ARL2 , TBCB , TBCA , TBCC , TBCD , TBCE , TUBA4A , TUBA3C , TUBB2A , TUBA1A , TUBA1B , TUBB3 , TUBB4A , TUBB4B , TUBA8 , TUBAL3 , TUBA4B , TUBB1 , TUBB6 , TUBA1C , TUBA3E , TUBA3D , TUBB2B ,