description
After translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the body. These modifications include the internal peptide bond cleavages that activate proenzymes, the attachment of oligosaccharide moieties to membrane-bound and secreted proteins, the attachment of lipid or glycolipid moieties that serve to anchor proteins to cellular membranes, and the vitamin K-dependent attachment of carboxyl groups to glutamate residues

external resources
NCBI:1268701
REACTOME:R-HSA-597592

genes
ACTB , ACTL6A , PARP1 , ADRB2 , ALPI , ALPL , ALPG , AMFR , ANK1 , ANK2 , ANK3 , APC , BIRC2 , BIRC3 , BIRC5 , AR , ARCN1 , AREG , ARF1 , ARF3 , ARF4 , ARF5 , RHOA , ARRB1 , ARRB2 , ARSA , ARSB , STS , ARSD , ARSE , ARSF , ART3 , ART4 , ASGR1 , ASGR2 , BARD1 , BGLAP , BLM , BMI1 , BRCA1 , BST1 , CALM1 , CALM2 , CALM3 , CALR , CANX , CCNA2 , CD59 , CDC20 , CDC25A , CDC34 , CDKN2A , CD52 , CEACAM5 , CETN2 , CTSC , CFTR , CGA , CEACAM7 , CHM , CHML , COL7A1 , COPA , COPB1 , CPM , CSNK1D , CTSZ , CYLD , DAD1 , CD55 , DAG1 , DCTN1 , DDB2 , DDOST , DHPS , DYNC1H1 , DYNC1I1 , DYNC1I2 , DYNC1LI2 , DPAGT1 , DPH1 , DPH2 , PHC1 , PHC2 , EEF1A1 , EEF2 , EIF5A , EP300 , ESR1 , ETFB , F2 , F5 , F7 , F8 , F9 , F10 , FCGR3B , FOLR1 , FOLR2 , FUCA1 , FUT3 , FUT8 , GALNT1 , GALNT2 , GALNT3 , GAS6 , GATA3 , KAT2A , GCNT1 , GFPT1 , GGCX , B4GALT1 , GLB1 , GMDS , GOLGA2 , GOLGB1 , GP2 , GPLD1 , GRIA1 , PDIA3 , HIST1H2AE , HIST1H2AD , HIST1H2BD , HIST1H2BB , HCFC1 , HIF1A , UBE2K , HNRNPC , HNRNPK , HSPA8 , IDE , FOXK2 , INCENP , INS , STT3A , KCNA6 , LHB , LMAN1 , LSAMP , LY6E , LY6H , SMAD1 , SMAD2 , SMAD3 , SMAD4 , SMAD7 , MAN1A1 , MAN2A2 , MAN2A1 , MDM2 , MDM4 , RAB8A , MELTF , MGAT1 , MGAT2 , MGAT3 , MGAT5 , MIA2 , MITF , ATXN3 , FOXO4 , MPI , MUC1 , MUC2 , MUC4 , MUC6 , MUC7 , MVD , MYC , NEDD8 , NEU1 , NEU2 , NFKBIA , NFRKB , NSF , NUP88 , NUP98 , OPCML , FURIN , CNTN3 , PRKN , PCNA , CFP , PGM3 , SERPINA1 , PIGA , PIGC , PIGF , PIGH , PLAUR , PML , PMM1 , PMM2 , POLB , CTSA , PPP6C , PRKCSH , PRKDC , PROC , PROS1 , PSMA1 , PSMA2 , PSMA3 , PSMA4 , PSMA5 , PSMA6 , PSMA7 , PSMB1 , PSMB2 , PSMB3 , PSMB4 , PSMB5 , PSMB6 , PSMB7 , PSMB8 , PSMB9 , PSMB10 , PSMC1 , PSMC2 , PSMC3 , PSMC4 , PSMC5 , PSMC6 , PSMD1 , PSMD2 , PSMD3 , PSMD4 , PSMD5 , PSMD7 , PSMD8 , PSMD9 , PSMD10 , PSMD11 , PSMD12 , PSMD13 , PSME1 , PSME2 , PTEN , RAB1A , RAB2A , RAB3A , RAB3B , RAB4A , RAB5A , RAB5B , RAB6A , RAB13 , RAB27A , RAB27B , RABGGTA , RABGGTB , RAB5C , RAD21 , RAD23A , RAD23B , RAD52 , RANBP2 , RANGAP1 , RENBP , RING1 , RNF2 , RNF5 , RPA1 , RPN1 , RPN2 , RPS2 , RPS27A , ATXN7 , SEC13 , TRAPPC2 , SEL1L , SIAH2 , ST6GAL1 , ST3GAL1 , ST3GAL2 , ST3GAL4 , ST3GAL3 , ST8SIA1 , SKP2 , SUMO3 , SUMO2 , SP3 , SP100 , UAP1 , SPTA1 , SPTAN1 , SPTB , SPTBN1 , SPTBN2 , AURKA , STX5 , TAF10 , MAP3K7 , TECTB , TDG , TECTA , TFAP2A , TFAP2B , TFAP2C , TGFA , TGFB1 , TGFBR1 , TGFBR2 , THBS1 , THBS2 , THY1 , TRAPPC10 , TNFAIP3 , TOP1 , TOP2A , TOP2B , TP53 , TP53BP1 , TPR , TRAF2 , TRAF3 , TRAF6 , TSTA3 , UBA52 , UBB , UBC , UBA1 , UBE2A , UBE2B , UBE2D1 , UBE2D2 , UBE2D3 , UBE2E1 , UBE2G1 , UBE2G2 , UBE2H , UBE2I , UBE2L3 , UBE2N , SUMO1 , UCHL1 , UCHL3 , UFD1 , UMOD , USP4 , VCP , VDAC1 , VDAC2 , VDAC3 , WRN , XPC , XPNPEP2 , XRCC4 , YY1 , PCGF2 , TRIM25 , MOGS , RNF103 , USP7 , RAB7A , ST8SIA4 , SEM1 , TUSC3 , PSCA , NUP214 , STAM , PTP4A2 , USP5 , AAAS , ST8SIA2 , USP11 , USP9X , SMC1A , TRRAP , AXIN1 , AXIN2 , BAP1 , HIST1H2AI , HIST1H2AK , HIST1H2AJ , HIST1H2AL , HIST1H2AC , HIST1H2AB , HIST1H2AM , HIST2H2AA3 , HIST2H2AC , HIST1H2BG , HIST1H2BL , HIST1H2BN , HIST1H2BM , HIST1H2BF , HIST1H2BE , HIST1H2BH , HIST1H2BI , HIST1H2BC , HIST1H2BO , HIST2H2BE , RECK , OGT , RAE1 , IKBKG , CBX4 , PIAS1 , LY6D , RUVBL1 , USO1 , DYNLL1 , TNKS , BECN1 , GALNT4 , B4GALT4 , B4GALT3 , B4GALT2 , SNX3 , GBF1 , GPAA1 , RIPK1 , RAB11A , RIPK2 , NAPG , NAPA , FPGT , DPM1 , DPM2 , KAT2B , PROZ , ST3GAL5 , VNN2 , VNN1 , CCNA1 , BCL10 , HERC2 , RAB29 , HIST1H2AG , HIST1H2BJ , USP13 , SEMA5A , PIAS2 , PIGQ , USP14 , USP2 , USP10 , USP8 , MTA1 , SEC22C , SMC3 , HGS , AURKB , LARGE1 , RAB11B , GCNT3 , COPB2 , B4GALT6 , B4GALT5 , RAB33A , RAB9A , COG1 , CHST10 , PIGL , PIGB , PSMF1 , ADAMTS4 , ADAMTS3 , ADAMTS2 , ADAMTS1 , MPDU1 , GOSR1 , RAB3D , GOSR2 , BABAM2 , RAB36 , NUP155 , SEC24C , CTR9 , MDC1 , NUP93 , EDEM1 , ADAMTSL2 , USP34 , CCP110 , MLEC , RNF144A , TOMM20 , RNF40 , KEAP1 , NUP58 , PSMD6 , TOMM70 , SEC24D , POM121 , SEC16A , JOSD1 , GFPT2 , USP15 , USP3 , NUP153 , RCE1 , GNE , PIGK , UBA2 , SAE1 , MUC12 , PREB , CHST4 , CNIH1 , ALG3 , PRMT3 , PSME3 , TRIM13 , PSMD14 , MSLN , STAM2 , STAG1 , BET1 , MARCH6 , TNIP1 , B3GNT3 , TFG , NOD1 , PIAS3 , ST3GAL6 , SPON2 , SPON1 , SEC24B , MCRS1 , TAB1 , COG5 , TADA3 , UBE2E3 , SEC23A , DCTN2 , SLC35A1 , POMT1 , USP16 , ST6GALNAC2 , STAMBP , YKT6 , RRAGA , DCTN6 , B3GNT2 , STAG2 , NUP50 , SEC24A , NEU3 , USP20 , USP19 , RAB10 , MAN1A2 , PRSS21 , KDELR1 , OS9 , TMED2 , LMAN2 , RAB40B , TMED10 , RAB32 , KDELR2 , KDELR3 , RAB35 , RAB31 , B4GAT1 , ADRM1 , UBE2C , TMEM115 , ADAMTS13 , ADAMTS8 , ADAMTS5 , NUPL2 , ADAMTS7 , ADAMTS6 , SEC23IP , GALNT6 , GALNT5 , RNF139 , MAN1B1 , DCTN3 , USP18 , MGAT4B , COPE , MGAT4A , COG2 , COPZ1 , COPG1 , DOLK , NTNG1 , PPP6R1 , SEC31A , ARSG , RAB18 , KIN , SCMH1 , RAB21 , USP33 , SMC5 , SSPO , NUP205 , RTF1 , ABRAXAS2 , GANAB , PSME4 , NUP210 , ANKRD28 , OTUD3 , SCFD1 , POFUT2 , NUP160 , USP22 , USP24 , TMED3 , ICMT , NUP188 , PIGN , DDX58 , PRND , NUP62 , RAB38 , FKBP8 , MGAT4C , RAB26 , COG4 , USP49 , SUMF2 , RWDD3 , ARFGAP3 , GALNT8 , SLC17A5 , COPG2 , SEC22A , USP21 , LYPD3 , ST6GALNAC4 , TRAPPC3 , RAB30 , UBE2S , MAT2B , C1GALT1C1 , BABAM1 , UBE2T , USP25 , SENP1 , TFPT , ALG5 , ST8SIA5 , GMPPB , GMPPA , ALG6 , POMT2 , ST6GALNAC6 , GALNT9 , NTM , AMDHD2 , DERL2 , TMED7 , UBXN1 , ST8SIA3 , SAR1B , DYNC1LI1 , A4GNT , DCTN4 , RAB9B , COPZ2 , PIGP , RNF181 , BET1L , NRN1 , GCNT4 , WAC , SPTBN5 , UCHL5 , TRAPPC4 , RAB14 , RAB6B , HDAC7 , PIAS4 , NOP58 , PIGT , DPH5 , TAF9B , PTRH2 , TRAPPC2L , RAB23 , UIMC1 , RAB8B , GALNT7 , NUP54 , RAB4B , RAB24 , CNTN5 , NANS , DPM3 , SEMA5B , ADAMTSL4 , INO80 , PAF1 , TMED9 , RAB39A , LY6K , ZRANB1 , NSMCE4A , PIGG , INO80D , UBE2R2 , PIGX , STX17 , USP47 , CDCA8 , UBA6 , ASXL2 , UBE2W , RHOT1 , PPP6R3 , SLC35C1 , VNN3 , YOD1 , GALNT10 , NAGK , OTUD5 , OTUB1 , POMGNT1 , RAB20 , PIGV , NDC1 , ARFGAP1 , EDEM2 , NUP133 , UGGT2 , NGLY1 , MBD5 , ST6GALNAC1 , THSD1 , CMAS , ALG1 , NSMCE3 , RNF20 , EIF5A2 , MUC13 , UGGT1 , C1GALT1 , OTUD7B , ADAMTS9 , RAB25 , NUP107 , MAN1C1 , DOLPP1 , ADAMTSL3 , CBX8 , RAB22A , GALNT16 , MAVS , COG6 , STAMBPL1 , WDR48 , USP28 , USP37 , SPTBN4 , RAB40C , TRAPPC1 , LY6G6D , SENP2 , RNF123 , NAPB , GALNT11 , CLSPN , FN3K , NOD2 , IFIH1 , RAB17 , CHST8 , GALNT17 , SUDS3 , GORASP1 , SMURF2 , ENGASE , GNPNAT1 , UBE2Z , OTUB2 , NUP37 , ALG8 , ALG12 , TRAPPC6A , METTL22 , DERL1 , TNIP2 , BRCC3 , B3GNT4 , CDC73 , RNF128 , MUL1 , VCPKMT , GALNT14 , ARSJ , SRD5A3 , FN3KRP , SMC6 , MANEA , GALNT12 , LMAN1L , ALG9 , CAMKMT , ALG13 , THSD4 , NUP85 , ACTR5 , TNIP3 , DHDDS , PHC3 , PGAP1 , ADAMTS20 , EDEM3 , ULBP2 , WDR61 , TNKS2 , THSD7B , LY6G6C , NPL , LMAN2L , ADAMTS12 , ADAMTS10 , RNF146 , ST6GALNAC5 , RAB1B , SEH1L , INO80B , RAB33B , DOHH , COG3 , TEX101 , TRAPPC9 , L3MBTL2 , USP26 , RAB34 , B3GNT5 , MAGT1 , USP44 , USP42 , ABRAXAS1 , USP48 , POMK , RNF135 , COG8 , ARFGAP2 , SYVN1 , DCTN5 , ST6GAL2 , NTNG2 , PIGO , CBX2 , USP30 , B3GNT9 , POMGNT2 , ALG10 , RAB2B , HIST1H2AH , HIST1H2BK , ALG2 , SEC16B , DPH6 , OTULIN , MCFD2 , IL33 , RNF185 , WDR20 , RFT1 , COG7 , ATXN3L , DPH7 , HIST3H2A , UBE2Q2 , ADAMTSL1 , B3GNT7 , PIGM , TADA2B , ACTR8 , PIGS , MUC16 , NLRP3 , MBD6 , MYSM1 , GALNT13 , RAB42 , RAB3C , NUS1 , LYPD1 , RAB39B , GALNT15 , MUCL1 , LARGE2 , DNAJC24 , TRAPPC6B , PSMB11 , LEO1 , SENP8 , NRN1L , B4GALNT2 , INO80C , TRAPPC5 , JOSD2 , HIST3H2BB , TBC1D20 , PIGU , NUP35 , NEU4 , LYPD6B , CD109 , LYPD2 , MUC17 , GCNT7 , DYNLL2 , ADAMTS14 , NANP , RAB40A , PSMA8 , MUC15 , ALG10B , B3GLCT , OTOA , B3GNTL1 , RTN4RL1 , LYPD4 , B3GALNT2 , CNIH3 , METTL21A , CNTN4 , ARSK , RAET1L , SBSPON , MDGA2 , OTUD7A , RNF168 , GALNTL5 , ADAMTS15 , ADAMTS16 , ADAMTS17 , ADAMTS18 , ADAMTS19 , ASXL1 , SPACA4 , B3GNT6 , EEF2KMT , FUK , NSMCE1 , ALG14 , MUC20 , RAB12 , SENP5 , USP12 , RNF152 , EEF1AKMT1 , HIST1H2AA , KDM1B , FOXK1 , THSD7A , ETFBKMT , CNIH2 , HIST1H2BA , NUDT14 , ST6GALNAC3 , NEGR1 , MDGA1 , FUOM , INO80E , PIGW , LYPD5 , SUMF1 , DPH3 , NSMCE2 , HIST2H2AB , RAB37 , GPIHBP1 , ST8SIA6 , RAB43 , ADAMTSL5 , ARSI , RAB41 , ARSH , NUP43 , PLET1 , RTN4RL2 , RAET1G , PRSS41 , GALNT18 , B3GNT8 , MIA3 , RAB15 , USP17L2 , IZUMO1R , USP17L8 , MUC21 , EEF1AKMT2 , RAB44 , C7orf76 , RAB19 , USP17L1 , MIR7-1 , ALG11 , HIST2H2BF , GALNTL6 , EID3 , SPRN , USP17L4 , USP17L3 , LYPD8 , HIST2H2AA4 , MUC5B , USP17L24 , USP17L25 , USP17L26 , USP17L5 , USP17L27 , USP17L28 , USP17L29 , USP17L30 , POM121C , USP17L10 , USP17L11 , USP17L12 , USP17L13 , USP17L17 , USP17L18 , USP17L19 , USP17L20 , USP17L21 , USP17L22 , USP17L15 , MIR1281 , MIR711 , MIR3620 , MIR3614 , MIR3656 , MIR3605 , MIR3610 , LOC100506136 , MIR4442 , NARR ,