description
Glycosylphosphatidyl inositol (GPI) acts as a membrane anchor for many cell surface proteins. GPI is synthesized in the endoplasmic reticulum. In humans, a single pathway consisting of eleven reactions appears to be responsible for the synthesis of the major GPI species involved in membrane protein anchoring.As a nascent protein fated to become GPI-anchored moves into the lumen of the endoplasmic reticulum, it is attacked by a transamidase complex that cleaves it near its carboxy terminus and attaches an acylated GPI moiety. The GPI moiety is deacylated, yielding a protein-GPI conjugate that can be efficiently transported to the Golgi apparatus

external resources
NCBI:1268710
REACTOME:R-HSA-163125

genes
ALPI , ALPL , ALPG , ART3 , ART4 , BST1 , CD52 , CEACAM5 , CEACAM7 , CPM , FCGR3B , FOLR2 , GP2 , GPLD1 , LSAMP , LY6E , LY6H , MELTF , OPCML , CNTN3 , PIGA , PIGC , PIGF , PIGH , PLAUR , TECTB , TECTA , THY1 , XPNPEP2 , PSCA , RECK , LY6D , GPAA1 , DPM1 , DPM2 , VNN2 , VNN1 , PIGQ , PIGL , PIGB , PIGK , MSLN , PRSS21 , NTNG1 , PIGN , PRND , LYPD3 , NTM , PIGP , NRN1 , PIGT , CNTN5 , DPM3 , LY6K , PIGG , PIGX , VNN3 , PIGV , LY6G6D , PGAP1 , ULBP2 , LY6G6C , TEX101 , NTNG2 , PIGO , PIGM , PIGS , LYPD1 , NRN1L , PIGU , LYPD6B , CD109 , LYPD2 , OTOA , RTN4RL1 , LYPD4 , CNTN4 , RAET1L , MDGA2 , SPACA4 , NEGR1 , MDGA1 , PIGW , LYPD5 , GPIHBP1 , PLET1 , RTN4RL2 , RAET1G , PRSS41 , IZUMO1R , SPRN , LYPD8 ,