description
N-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway is highly conserved in eukaryotes, and a closely related pathway is found in many eubacteria and Archaea. Mutations in the genes associated with N-glycan precursor synthesis lead to a diverse group of disorders collectively known as Congenital Disorders of Glycosylation (type I and II) (Sparks et al. 1993). The phenotypes of these disorders reflect the important role that N-glycosylation has during development, controlling the folding and the properties of proteins in the secretory pathway, and proteins that mediate cell-to-cell interactions or timing of development

external resources
NCBI:1268715
REACTOME:R-HSA-446193
PUBMED:20301507

genes
DPAGT1 , GFPT1 , GLB1 , GMDS , MPI , MVD , NEU1 , NEU2 , PGM3 , PMM1 , PMM2 , CTSA , RENBP , ST6GAL1 , ST3GAL1 , ST3GAL2 , ST3GAL4 , ST3GAL3 , ST8SIA1 , UAP1 , TSTA3 , ST8SIA4 , ST8SIA2 , FPGT , DPM1 , DPM2 , ST3GAL5 , MPDU1 , GFPT2 , GNE , ALG3 , ST3GAL6 , SLC35A1 , ST6GALNAC2 , NEU3 , DOLK , SLC17A5 , ST6GALNAC4 , ALG5 , ST8SIA5 , GMPPB , GMPPA , ALG6 , ST6GALNAC6 , AMDHD2 , ST8SIA3 , NANS , DPM3 , SLC35C1 , NAGK , ST6GALNAC1 , CMAS , ALG1 , DOLPP1 , GNPNAT1 , ALG8 , ALG12 , SRD5A3 , ALG9 , ALG13 , DHDDS , NPL , ST6GALNAC5 , ST6GAL2 , ALG10 , ALG2 , RFT1 , NUS1 , NEU4 , NANP , ALG10B , FUK , ALG14 , NUDT14 , ST6GALNAC3 , FUOM , ST8SIA6 , ALG11 ,