description
Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar

external resources
NCBI:83044
KEGG:hsa03420
PUBMED:11436323
PUBMED:18018633
PUBMED:11436316
PUBMED:17884153
PUBMED:11436314
PUBMED:17276014
PUBMED:16922398

genes
CCNH , CDK7 , CETN2 , ERCC8 , DDB1 , DDB2 , ERCC1 , ERCC2 , ERCC3 , ERCC4 , ERCC5 , ERCC6 , GTF2H1 , GTF2H2 , GTF2H3 , GTF2H4 , LIG1 , MNAT1 , PCNA , POLD1 , POLD2 , POLE , POLE2 , RAD23A , RAD23B , RFC1 , RFC2 , RFC3 , RFC4 , RFC5 , RPA1 , RPA2 , RPA3 , XPA , XPC , CUL4B , CUL4A , RBX1 , POLD3 , RPA4 , POLE3 , POLE4 , POLD4 , GTF2H5 , GTF2H2C , BIVM-ERCC5 ,