description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR

external resources
NCBI:83046
KEGG:hsa03440
PUBMED:12589470
PUBMED:15902993
PUBMED:16935872
PUBMED:17395553
PUBMED:18086882
PUBMED:17571595
PUBMED:18430459

genes
ATM , BARD1 , BLM , BRCA1 , BRCA2 , MRE11 , NBN , POLD1 , POLD2 , RAD51 , RAD51C , RAD51B , RAD51D , RAD52 , RBBP8 , RPA1 , RPA2 , RPA3 , SSBP1 , TOP3A , XRCC2 , XRCC3 , SEM1 , RAD54L , TOP3B , BABAM2 , RAD50 , POLD3 , TOPBP1 , RAD54B , BABAM1 , RPA4 , SYCP3 , UIMC1 , POLD4 , BRCC3 , PALB2 , MUS81 , BRIP1 , ABRAXAS1 , EME1 ,