description
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone

external resources
NCBI:83047
KEGG:hsa03450
PUBMED:17506672
PUBMED:15578053
PUBMED:16971555
PUBMED:17589524
PUBMED:12215643
PUBMED:16895466

genes
DNTT , FEN1 , XRCC6 , LIG4 , MRE11 , PRKDC , XRCC4 , XRCC5 , RAD50 , POLL , POLM , DCLRE1C , NHEJ1 ,