description
The Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER during times of unusually high secretion activity. Analysis of mutants with altered UPR, however, shows that the UPR is also required for normal development and function of secretory cells.One level at which the URP operates is transcriptional and translational regulation: mobilization of ATF6 and IRE1 leads to increased transcription of genes encoding chaperones, and mobilization of PERK (pancreatic eIF2alpha kinase, EIF2AK3) leads to phosphorylation of the translation initiation factor eIF2alpha and global down-regulation of protein synthesis. These three regulatory pathways are annotated here

external resources
NCBI:1268756
REACTOME:R-HSA-381119
PUBMED:18436705
PUBMED:18038217
PUBMED:27067637
PUBMED:16365312
PUBMED:18048764
PUBMED:15952902

genes
ACADVL , ADD1 , ASNA1 , ASNS , ATF3 , ATF4 , CALR , TPP1 , DCTN1 , DDIT3 , DDX11 , EIF2S1 , ERN1 , EXTL3 , GFPT1 , GSK3A , HDGF , HSPA5 , IGFBP1 , CXCL8 , LMNA , DNAJB9 , NFYA , NFYB , NFYC , PARN , EXOSC9 , PPP2R5B , DNAJC3 , CCL2 , SHC1 , SRPRA , SSR1 , SULT1A3 , TLN1 , SEC62 , HSP90B1 , WFS1 , XBP1 , ZBTB17 , KHSRP , MBTPS1 , ATP6V0D1 , EIF2AK3 , GOSR2 , EDEM1 , HERPUD1 , TATDN2 , CUL7 , CTDSP2 , PREB , PDIA6 , HYOU1 , YIF1A , SEC61B , PDIA5 , KDELR3 , SEC63 , EXOSC8 , SEC31A , DIS3 , ATF6 , EXOSC7 , EXOSC2 , SEC61G , SERP1 , SEC61A1 , CXXC1 , EXOSC3 , EXOSC1 , MBTPS2 , DNAJB11 , EXOSC4 , FKBP14 , WIPI1 , SEC61A2 , ARFGAP1 , MYDGF , EXOSC5 , SRPRB , TSPYL2 , SYVN1 , KLHDC3 , EXOSC6 , DCP2 , PLA2G4B , MIR3652 , MIR3940 ,