description
ATF6-alpha is a transmembrane protein that normally resides in the Endoplasmic Reticulum (ER) membrane. Here its luminal C-terminal domain is associated with BiP, shielding 2 Golgi-targeting regions and thus keeping ATF6-alpha in the ER. Upon interaction of BiP with unfolded proteins in the ER, ATF6-alpha dissociates and transits to the Golgi where it is cleaved by the S1P and S2P proteases that reside in the Golgi, releasing the N-terminal domain of ATF6-alpha into the cytosol. After transiting to the nucleus, the N-terminal domain acts as a transcription factor to activate genes encoding chaperones
external resources
NCBI:1268757
REACTOME:R-HSA-381033
PUBMED:25821458
PUBMED:18048764
PUBMED:18038217
PUBMED:18436705
genes
ATF4
,
CALR
,
DDIT3
,
HSPA5
,
NFYA
,
NFYB
,
NFYC
,
HSP90B1
,
XBP1
,
MBTPS1
,
ATF6
,
MBTPS2
,
MIR3652
,
