description
The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins

external resources
NCBI:1268758
REACTOME:R-HSA-381183
PUBMED:10866666
PUBMED:14973138
PUBMED:12014989
PUBMED:25821458
PUBMED:10856300
PUBMED:10958673

genes
ATF4 , CALR , DDIT3 , HSPA5 , NFYA , NFYB , NFYC , HSP90B1 , XBP1 , ATF6 , MIR3652 ,