description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli

external resources
NCBI:83048
KEGG:hsa04010
PUBMED:11749383
PUBMED:12566928
PUBMED:12849693
PUBMED:12676795
PUBMED:12947395
PUBMED:14597384
PUBMED:11369511
PUBMED:12191611
PUBMED:12390245

genes
AKT1 , AKT2 , FAS , FASLG , ARRB1 , ARRB2 , ATF4 , BDNF , BRAF , CACNA1A , CACNA1B , CACNA1C , CACNA1D , CACNA1E , CACNA1F , CACNA1S , CACNA2D1 , CACNB1 , CACNB2 , CACNB3 , CACNB4 , CACNG1 , CASP3 , CD14 , CDC25B , CDC42 , CHUK , MAP3K8 , ATF2 , CRK , CRKL , MAPK14 , DAXX , GADD45A , DDIT3 , DUSP1 , DUSP2 , DUSP3 , DUSP4 , DUSP5 , DUSP6 , DUSP7 , DUSP8 , DUSP9 , EGF , EGFR , ELK1 , ELK4 , MECOM , FGF1 , FGF2 , FGF3 , FGF4 , FGF5 , FGF6 , FGF7 , FGF8 , FGF9 , FGF10 , FGF11 , FGF12 , FGF13 , FGF14 , FGFR1 , FGFR3 , FGFR2 , FGFR4 , FLNA , FLNB , FLNC , FOS , GNA12 , MKNK2 , GRB2 , NR4A1 , HRAS , HSPA1A , HSPA1B , HSPA1L , HSPA2 , HSPA6 , HSPA8 , HSPB1 , IKBKB , IL1A , IL1B , IL1R1 , JUN , JUND , KRAS , STMN1 , MAPT , MAX , MEF2C , MAP3K1 , MAP3K3 , MAP3K4 , MAP3K5 , MAP3K11 , MOS , MYC , GADD45B , NF1 , NFATC1 , NFATC3 , NFKB1 , NFKB2 , NGF , NRAS , NTF3 , NTF4 , NTRK1 , NTRK2 , PAK1 , PAK2 , PDGFA , PDGFB , PDGFRA , PDGFRB , PLA2G4A , PPM1A , PPM1B , PPP3CA , PPP3CB , PPP3CC , PPP3R1 , PPP3R2 , PPP5C , PRKACA , PRKACB , PRKACG , PRKCA , PRKCB , PRKCG , MAPK1 , MAPK3 , MAPK7 , MAPK8 , MAPK11 , MAPK9 , MAPK10 , MAPK13 , MAP2K1 , MAP2K2 , MAP2K3 , MAP2K5 , MAP2K6 , MAP2K7 , PTPN7 , PTPRR , MAP4K2 , RAC1 , RAC2 , RAC3 , RAF1 , RAP1A , RAP1B , RASA1 , RASA2 , RASGRF1 , RASGRF2 , RELA , RELB , RPS6KA1 , RPS6KA2 , RPS6KA3 , RRAS , MAPK12 , MAP2K4 , SOS1 , SOS2 , SRF , STK3 , STK4 , MAP3K7 , TGFB1 , TGFB2 , TGFB3 , TGFBR1 , TGFBR2 , TNF , TNFRSF1A , TP53 , TRAF2 , TRAF6 , MAP3K12 , IL1R2 , MAPKAPK3 , FGF23 , MAP4K3 , IKBKG , MAPKAPK5 , MKNK1 , PLA2G4C , LAMTOR3 , JMJD7-PLA2G4B , FGF18 , FGF17 , FGF16 , CACNA1I , CACNA1H , CACNA1G , RPS6KA4 , MAP3K14 , MAP3K6 , MAP3K13 , RPS6KA5 , CACNA2D2 , MAPKAPK2 , TAOK2 , MAP4K4 , MAPK8IP1 , RAPGEF2 , FGF19 , AKT3 , RASGRP1 , RASGRP2 , CACNG3 , CACNG2 , TAB1 , MAP3K2 , GADD45G , MAP4K1 , DUSP10 , RRAS2 , MRAS , TAB2 , MAPK8IP3 , MAPK8IP2 , RASGRP3 , FGF20 , FGF21 , FGF22 , CACNG5 , CACNG4 , RPS6KA6 , ECSIT , TAOK3 , NLK , MAP3K20 , CACNA2D3 , GNG12 , TAOK1 , CACNG8 , CACNG7 , CACNG6 , DUSP16 , PTPN5 , CACNA2D4 , RASGRP4 , PLA2G4E , PLA2G4F , PLA2G4D , PLA2G4B , PPP5D1 ,