description
Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER

external resources
NCBI:1268760
REACTOME:R-HSA-381038
PUBMED:16461360
PUBMED:16539657
PUBMED:17612490
PUBMED:14559994
PUBMED:18664523

genes
ACADVL , ADD1 , ASNA1 , TPP1 , DCTN1 , DDX11 , EXTL3 , GFPT1 , GSK3A , HDGF , LMNA , DNAJB9 , PPP2R5B , DNAJC3 , SHC1 , SRPRA , SSR1 , SULT1A3 , TLN1 , SEC62 , WFS1 , XBP1 , ZBTB17 , ATP6V0D1 , GOSR2 , EDEM1 , TATDN2 , CUL7 , CTDSP2 , PREB , PDIA6 , HYOU1 , YIF1A , SEC61B , PDIA5 , KDELR3 , SEC63 , SEC31A , SEC61G , SERP1 , SEC61A1 , CXXC1 , DNAJB11 , FKBP14 , WIPI1 , SEC61A2 , ARFGAP1 , MYDGF , SRPRB , TSPYL2 , SYVN1 , KLHDC3 , PLA2G4B ,