description
The action potential travels down the axon and reaches the pre-synaptic terminal depolarizing the membrane in the pre-synaptic terminal. The depolarization causes the voltage-gated Ca2+ channels to open allowing the influx of Ca2+ that signals the release of neurotransmitter into the synaptic cleft

external resources
NCBI:1268767
REACTOME:R-HSA-112308

genes
CACNA1A , CACNA1B , CACNA1E , CACNA2D1 , CACNB1 , CACNB2 , CACNB3 , CACNB4 , CACNA2D2 , CACNG2 , CACFD1 , CACNG4 , CACNA2D3 ,